AN eighth person has died from a vaping as an outbreak of mysterious lung diseases continues to grip the US.
Officials warned of a sharp spike in cases of the e-cigarette-linked condition - with 530 people now affected.
The man, in his mid-forties, had normal lung function until he took up vaping in May, health officials in Missouri said.
He developed mild respiratory symptoms that worsened and he was taken to hospital on August 22, where he later died.
Dr Michael Plisco, critical care pulmonologist at Mercy Hospital St. Louis, said: "He started out with shortness of breath and it rapidly progressed and deteriorated, developing into what is called acute respiratory distress syndrome (ARDS).
"Once the lungs are injured by vaping, we don't know how quickly it worsens and if it depends on other risk factors."
It's the latest death following a spike in people being struck down with mysterious and life-threatening lung diseases in the US.
The Centers for Disease Control and Prevention said 530 confirmed and probable cases have been reported in 38 states and one US territory - up from 380 a week ago.
The growing toll has prompted officials to launch a criminal investigation.
However, they are still struggling to identify a single product or chemical in e-cigarettes behind the outbreak.
Mitch Zeller, a director at the Food and Drug Administration, said: “The focus is on the supply chain.”
The illness was first reported in April and all patients are known to have used e-cigarettes — some containing the cannabinoid THC.
Symptoms can include fatigue, coughing, breathlessness and vomiting or diarrhoea.
States have begun banning e-cigarette sales and the first case has been reported in Canada.
Anne Schuchat, from the Center for Disease Control, urged vapers to give up. On the deaths, she said: “We do expect others.”
It came a day after India said it was banning e-cigarette sales and imports.
In the UK, e-cigarettes are tightly regulated for safety and quality.
They're not completely risk free, but they carry a small fraction of the risk of cigarettes.
E-cigarettes do not produce tar or carbon monoxide, two of the most harmful elements in tobacco smoke.
The liquid and vapour contain some potentially harmful chemicals also found in cigarette smoke, but at much lower levels.
While nicotine is the addictive substance in cigarettes, it's relatively harmless.
Almost all of the harm from smoking comes from the thousands of other chemicals in tobacco smoke, many of which are toxic.
Nicotine replacement therapy has been widely used for many years to help people stop smoking and is a safe treatment.
There's no evidence so far that vaping causes harm to other people around you.
This is in contrast to secondhand smoke from smoking, which is known to be very harmful to health.
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The first death identified as related to vaping was announced last month in Illinois where a patient had suffered a "severe respiratory illness" after vaping.
In July, a person in Oregon who had recently used vapes containing cannabis oil died.
Another death was reported on September 6 by health officials in Indiana, who said the patient was over 18 and had a history of e-cigarette use.
Minnesota Department of Health announced on the same day that a patient had died in August from a lung disease associated with vaping THC - the psychoactive chemical in cannabis - products.
Two deaths were announced in Los Angeles County and Kansas, last week.
Then earlier this week, a 40-year-old man in California died after battling a "severe" lung disease linked to vaping for several weeks.
On Monday, the agency said it has activated its emergency operations centre to coordinate the investigation.
CDC Director Robert Redfield said: "CDC has made it a priority to find out what is causing this outbreak of e-cigarette or vaping-related injuries and deaths."
While the cases have not yet been linked to a specific product or ingredient, health officials have urged consumers to quit vaping altogether.
Health investigators are trying to establish whether a particular toxin or substance is being added into products, including marijuana, or whether it stems from heavy usage.
The US Food and Drug Administration (FDA) believes vape liquid containing THC - the psychoactive agent in cannabis - could be to blame and have issued a warning.
But many patients have said they have no knowledge about the substances they might have used - making treatment complicated.
For those who continue, the CDC is urging consumers to avoid buying vaping products on the street, using marijuana-derived oil with the products or modifying a store-bought vape product.
Anyone who has breathing problems after vaping, such as a dry, or unproductive cough, shortness of breath and chest pain that worsens with deep breathing, should report them to their doctor.
British health experts have also raised concerns over the health risks of vaping - but Public Health England said they are not aware of any similar incidents in the UK.
Vaping has been recommended to smokers trying to quit nicotine - and they're claimed to be up to 95 per cent less harmful than cigarettes.
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