But his recent appearances on the personalized video site Cameo, on which he charges an eye-watering $999 for a 20-second post, have resulted in a flurry of tweets from fans concerned about his health.
In one clip, Matthew can be seen close to the camera and squinting as he wishes a fan named Rachel congratulations on her own engagement and upcoming birthday.
One fan wrote on Twitter: “Seriously starting to get worried about , man the dude doesn't look well and in his recent "Cameo" videos he's slurring his words. Even the fact he's ON "Cameo" doesn't bode well for me.”
A second added: “I just watched it. Awful. Was Matthew Perry slurring his words on purpose or is that how he sounded.”
“I truly hope it's only age and nothing serious. Also he uses front camera too low which makes his face looks unflattering,” a third added.
Another fan on the social media site branded his appearance “sad and worrying”, while another said she was “lost for words”.
Matthew is charging almost $1,000 (around £830) per video on the site, although some have questioned the actor’s pricing given he’s worth a reported $120million.
One fan wrote on Twitter: “Matthew Perry’s on Cameo and it’s £830. Sorry, I’m a Friends NUT obsessive, but that shouldn’t even be allowed! You are a millionaire Matt, do better.”
Matthew has five public videos featured on the site, and followers can also join his fan club to unlock additional content.
Dressed in a checked blue shirt with unruly gray hair, he is heard saying in one clip: “Hello Rachel, how are you?
“This is Matthew Perry and I wanted to use this Cameo to congratulate you on all these wonderful things that are happening in your life.
“Zac let me know that you’re getting married, that you have a big birthday coming up, and I think these are all wonderful things.
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“And I wish you and Zac a wonderful marriage, and I hope you have a wonderful birthday. 30 was a great year for me, I hope it’s a great year for you, and it’s good to be able to talk to you virtually.”
The actor, who played quirky Chandler Bing in the sitcom Friends, then quipped: “Oh and I’m wearing no pants.”